Ingen mistanke om fosterskadelig effekt ved ordinary dosering. Ved intoksikasjoner er det høy frekvens av fosterdød og spontanaborter
GraviditetEn stor mengde info fra gravide indikerer hverken misdannelser eller toksisitet av paracetamol hos foster/nyfødt barn. Epidemiologiske studier på nevronal utvikling hos barn eksponert for paracetamol in utero viser ikke entydige resultater. Ved langvarig behandling med kodein hos mor underneath graviditet er det sett neonatal abstinens. Det er sett neonatal respirasjonsdepresjon ved bruk av kodein ved fileødsler. Paralgin forte/Paralgin big skal bare brukes less than graviditet hvis fordel oppveier mulig risiko, og da med lavest mulig effektiv dose i kortest mulig tid og lavest mulig frekvens.
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Overdose and liver toxicity Acetaminophen overdose may be manifested by renal tubular necrosis, hypoglycemic coma, and thrombocytopenia. Often, liver necrosis can manifest along with liver failure.
Codeine binds to mu-opioid receptors, which might be involved with the transmission of pain through the physique and central anxious system , . The analgesic Qualities of codeine are thought to come up from its conversion to Morphine, although the specific system of analgesic action is mysterious at this time , .
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EMA ble opprettet i 1995 for å sikre ideal mulig utnyttelse av Europas vitenskapelige ressurser for evaluering av, tilsyn med og overvåkning av paralgin forte mot ryggsmerter legemidler.
The share of a systemically absorbed rectal dose of acetaminophen is inconsistent, demonstrated by significant variations while in the bioavailability of acetaminophen following a dose administered rectally.
Higher rectal doses or an increased frequency of administration can be utilized to attain blood concentrations of acetaminophen similar to People attained just after oral acetaminophen administration. Absorption